Anton Goloborodko

B.Sc. in Applied Physics and Math, Moscow Institute of Physics and Technology, 2008; M.Sc. in Applied Physics and Math, Moscow Institute of Physics and Technology, 2010; Ph.D. in Physics, Massachusetts Institute of Technology, 2018; postdoc at Massachusetts Institute of Technology.

The Goloborodko group focuses on soft-matter physics in biology: development of coarse-grained computer simulations and pen-and-paper theoretical models. In particular, they work on the reconstruction of ensembles of 3D genome structures from Hi-C and microscopy data, design of mechanistic models of genome folding by active enzymes and development of software for high-throughput analysis of biological sequencing data with the focus on Hi-C experiments. As some of their most important contributions, they together with collaborators built the first polymer model of genome compaction and segregation by loop extrusion in mitosis, developed a detailed model of mitotic chromosome organization, demonstrated that cohesin and CTCF form interphase loops by extrusion and developed multiple software packages for analysis and interpretation of Hi-C data, such as hiclib, pairtools and cooltools.